Tuesday, November 15, 2016 11:47:19 AM
Look how this remark echoes and reinforces comments by Dr. Perlmutter, head of IO research at Merck, in an October ESMO article on Keytruda vs. Opdivo. Dr. Perlmutter explained that higher levels of PD-L1 confer a greater benefit from PD-1 blockers and “It turns out PD-L1 expression is just a marker for the presence of an immune response.” Here is a quote from the article:
http://www.cnbc.com/2016/10/07/bristol-myers-mercks-lung-cancer-treatments-square-off-this-weekend.html
This is why Wolchok’s comment yesterday is so important when he confirmed that Bavi’s MOA is to “create a more immune active environment”:
The really important part of the MSK poster, the part that will wake up all the BP decision makers, is not the mice survival data but rather all the detailed work MSK did to confirm that Bavi is indeed triggering an upstream immune response, e.g. increase in CD8 T-cells, shift of macrophage from M2 to M1. MSK summarizes this “creation of a more active immune environment” in the 3rd and 4th bullet points of the Poster Conclusion. This is just what Dr. Perlmutter at Merck said was missing in the 80% of patients that don’t respond to PD-1. To quote Perlmutter, Keytruda and Opdivo work better when the clinician can say "Gee, there's already an immune response going on here."
There is now strong evidence from the MSK poster and Wochok’s summary comments that Bavi triggers an upstream immune response. This will be a huge boost to the ongoing partnership talks.
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